PART I
PATHWAY CURATION TOOLS AND APPLICATION
Complexity: Guess which body was not designed to stand turbulence?
Post genomic era has opened up huge database cataloguing the molecular parts of biological systems; Comprehansive knowledge of isolated systems available 'in vitro' and in vivo; Comprehanding paradigm shift
Computational Approach:
Model-Modify-Mine-Measure
Biological Modelling and simulation:
Body waeight> Tissue/cells > Protein > Genes (Top-Down: increasing complexity but Bottom-Up: increasing abstraction)
System biology Approach: network model construction (clinical data, animal models, biologicalliterature); network property analysis (pathway length distribution, node centrality distribution, network degree distribution); high granularity pathway dynamic modelling (celldesigner.org)
Computational Platform:
GN (graphical notation), SBML, CellDesigner.org, CellDesigner Applet, Public Donation Database
PART II
Mtb Mappathon
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