Teen Murti Bhawan
01:02:00 PM
Map: the view of world
Google Map
EGF Receptor Cascade
Garuda Project (Vishnu ride)
oncology, CNS, Cardio, Infection- Garuda common Platform
Cell Designer-modelling tool
PAYAO: SBML Models Tagging System
Community Curation Platform- How to maintain Map?
Pathway Curation Suite-
why drug discovery is difficult?
Multiple genes cause many diseases.
Internet Router Topology - Human PPI
Robustness includes Homeostasis & Stability but not equal
Complete Robust System- cancer robustness-source of robustness-feedback loop within cell-
Intra Tumor Heterogeneity
Robustness Trade-offs
Robustness - Fragility
Bode Theorem
Collateral Sensitivity: Fragility Vs Resistance.
The conjecture- reduce cost & efficacy & sensitivity when two combination s of drug turn to cure other disease.
Open Pharma
Robustness - based target candidate selection, differential robustness
current question- which genes are over-expresing/mutant /missing in tumor cells?
computational fluid dynamics- big sucess-homogeous system
large network map-dynamic model construction- mechanism of AKT effect
the era of new drug design- what are problems, what need to be done, how to do it, we are crazy to mad the solution
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment