Glycosylation
carbohydrate interactions in a cell.
Why glycans?
Glycans: potential drug targets for drugs, vaccine candidates, enzymes processing glycans catalyze steps in growth, proliferation and infection diseases.
Through th Looking Glass--
Glycome in infection development: microbial adhesion > host penetration > host damage
Glycosysltion present in both prokaryotes and eukaryotes
Two types of glycans: N-Glycans and O-Glycans
Key components for targeting glycome: enzymes responsible for makin glycoconjugate; protein responsible for making cell surface.
Challenges for annotatinng the Mtb glycome: not much available literature.
Organisation of Glycome in Mtb:
Re-annotating Mtb using the power of collaboration
Search for homologues of glycans
Function prediction of unknown proteins
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